Non-invasive screening of breast cancer from fingertip smears - a proof of concept study

Summary

This collection includes MALDI MS filedata underpinning the study by Russo et al entitled "Non-invasive screening of breast cancer from fingertip smears : a proof of concept study" and published in Scientific Reports. In particular the files correspond to the acquisition of MALDI MS spectra from the fingertip smears of 15 patients split in three diagnostic catergories: healthy, early breast cancer and metastatic. Mass Spectra data have been supplied in three formats: raw spectra (in the proprietary Waters Corp Synapt G2 HDMS format), exported as text files after processing (.txt) and as the associated processed dataset that has been used for downsteam ML (.csv). Additionally, a Jupyter notebook containing all the data pre-processing steps, and also the subsequent undersupervised learning analysis.

Keywords:	MALDI MS, breast cancer, machine learning, sweat, fingerprint, MALDI
Creators:	Francese, Simona http://orcid.org/0000-0002-1381-1262
Academic units:	Faculty of Health and Wellbeing (HWB) > Research Centres > Biomolecular Sciences Research Centre (BSRC)
Funders:	Funder Name Grant Number Funder ID Sheffield Hallam University Confidence in Concept UNSPECIFIED
Publisher of the data:	SHU Research Data Archive (SHURDA)
Publication date:	21 November 2022
Data last accessed:	1 April 2024
DOI:	http://doi.org/10.17032/shu-180040
SHURDA URI:	https://shurda.shu.ac.uk/id/eprint/166
Additional details Additional details Types of data: Dataset Collection period: From To 1 December 2018 5 January 2020 Geographic coverage: England, Sheffield Hallam University Data collection method: 1) MALDI Mass spectrometry analysis 2) Machine learning algorithm development Data processing and preparation activities: Mass Spectrometry data were processed by Simona Francese and laura Cole (SHU staff) and Cristina Russo and Cameron Heaton at the time PDRA and PhD student respectively. Machine learning processing was executed by Marjory da Costa-Abreu (SHU staff) and Charles Bury (Exscentia, Oxford) Statement on legal, ethical and access issues: Patients' fingertip smears were collected following full Ethics and research governance approval (IRAS ID 253281, REC reference 18/LO/1792) at a single UK breast unit. Resource language: English Metadata language: English Depositing User: Simona Francese Date Deposited: 19 Dec 2022 08:41 Last Modified: 19 Dec 2022 08:41