Drug facilitated sexual assault (DFSA) is an issue of growing concern. As these drugs are metabolised very quickly, toxicological evidence from biological fluids, corroborating the victim’s statement, is challenging to recover, especially with late reports. Ihe data collected and deposited here pertain to the development of an additional method involving the analysis of the victim’s fingermarks recovered at the scene(s) of the crime, which may contain the parent drug and its metabolite.In this light, the dataset deposited includes the raw imaging and profiling data acquired using Matrix Assisted Laser Desorption Ionisation Mass Spectrometry Imaging, Desorption Electrospray Ionisation Mass Spectrometry Imaging and Soft Ionisation by Chemical Reaction In Transfer from fingermarks contaminated with risperidone and/or its pharmacologically active metabolite paliperidone as a case study.